Little Biology Homework help please?

A. Sickle-cell Anemia is a disease caused by a mutation in the gene that codes for hemoglobin (the protein in red blood cells that carries oxygen). The bad allele (sickle cell gene) has just a single DNA nucleotide that is different from what the normal hemoglobin gene has – one nucleotide has been exchanged for a different one. Use your knowledge of mutation, transcription, protein synthesis, and protein structure and function to explain how such a small change can cause a deadly disease in eight different points.